Posts tagged Arthritis

Mountain Healing

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In 1776, while the Declaration of Independence was being drafted, the great French botanist Andre Michaux stood atop North Carolina’s Grandfather Mountain and sang the French national anthem. It was a moment that represented the culmination of years of exploration into the magnificent variety of plants that flourish in the southern Appalachians — a concentration of flora unequaled on the North American continent or even in the whole of Europe.

As significant as was the work of Michaux, Native American tribes such as the Cherokee and the Catawba had been roaming the lush hillsides and gorges for centuries before his time, discovering a multitude of uses for these plants — one of the most significant being medicinal. The region is a veritable outdoor pharmacy of medicinal plants, which were not only part of the recipes of yesterday’s tribal medicine men, but continue to occupy a place in today’s pharmacopoeias. In fact, so important are the botanical sources of modern medicines that environmental scientist G. Tyler Miller has estimated that 40 percent of all the medicine on the shelves of today’s drugstores have plant origins.

While any attempt at a complete listing of known medicinal plants of the southern Appalachians might require volumes, a brief walk along their paths will, I hope, serve to illustrate the enormous impact the area has had on modern medical practice.

Let’s begin with a heart medication. A member of the figwort family, growing 2 to 5 feet in height, is the purple foxglove (Digitalis purpurea). With lance-shaped to oval leaves, these spires of thimble-like flowers — from white to pinkish lavender to red bloom from June to September. This beautiful plant is the source of digitalis, a cardiac stimulant extracted from the leaves that has kept millions of heart patients alive.

Foxglove is among the loveliest, most famous, most important and most dangerous of medicinal plants. Used improperly, it is as likely to stop a heart as it is to keep it going.

Its usefulness was first discovered in 1775 by the English physician William Withering. He had heard of an old woman who practiced folk medicine with herbs gathered from the countryside. A patient afflicted with excessive fluid retention caused by congestive heart failure, who Withering expected to die, was cured by this healer. From this woman’s bag of weeds, Withering identified foxglove as the key element in treating swelling or edema associated with congestive heart failure. The paper he published in 1785 to inform other physicians of his findings is a classic of medical literature.

From heart medicine we move to what some have called the “Prozac of Europe.” St. John’s wort (Hypericum perforatum) is native to Europe but grows throughout the eastern United States, including the southern highlands. An erect perennial shrub with bright yellow flowers from June through September, it has found extensive use as a treatment for depression in European medical practice. It is beginning to enjoy increased usage in the United States; however, caution should be exercised in its use since St. John’s wort contains hypericin, a photosensitory substance that reacts with light to cause skin burns in some people.

A traditional astringent (skin cleaner) and ingredient in numerous other pharmaceutical products is witch hazel (Hamamelis virginiana). It is a bush of the southern mountains that surprises us by blooming in autumn rather than spring, putting on a colorful display of bright yellow flowers that grow in feathery clusters. The name, witch hazel, developed from its reputed properties as a divining rod; folklore tells of the plant’s tendency to bend toward the Earth when held over underground water.

Witch hazel is extremely important commercially. The extract made by distilling the bark and leaves in alcohol has been used by pharmacists for more than a century. Bottles on the shelves of drugstores worldwide have labels recommending use of the extract for bruises, insect bites, sun burn, poison ivy rash and as an aftershave lotion.

Still another abundant medicinal plant of southern Appalachia is the mayapple, known botanically as Podophyllum peltatum. These plants usually grow in clusters with umbrella-like leaves, a white inconspicuous flower, and a small greenish yellow fruit, whose sweet taste makes it ideal for jams, jellies and preserves. A medicinal substance called podophyllum is obtained from the dried powdered root and, compounded with tincture of benzoin, is used as a caustic for the removal of warts and other papillomas.

During the warm months of August and September, when little else blooms in the fields and hillsides, the light blue flowers of Indian tobacco (Lobelia inflata) grace the landscape. The stems are yellow to purplish, quite hairy, and branched about midway. Its medicinal substance is an alkaloid called lobeline, which is derived from the leaves and tops of the plant, which, when dried to a powder, are greenish-yellow in color. Lobeline is used as a respiratory stimulant and for the treatment of spasmodic bronchitis and chronic emphysema. Its popular name comes from the fact that American Indians once smoked its leaves to relieve asthma and other ailments. In recent years, lobeline has also found use as an ingredient in preparations designed to help people curb the smoking habit.

Continuing our walk along the paths of the southern Appalachians, we see brilliant splashes of pumpkin-orange flowers signifying the presence of butterfly weed (Asclepias tuberosa). The name is appropriate because monarchs, swallowtails and other butterflies are especially attracted to this member of the milkweed family when it is in bloom. Although no longer used in modern medicine because of the highly toxic glycosides in its roots, butterfly weed was long used by Native Americans, who powdered the roots and mixed them into a paste to spread on sores, as well as brewed its leaves to induce perspiration and expectoration in people with severe respiratory ailments such as pleurisy. Hence one of its alternative names: pleurisy root.

In early spring in the moist rich recesses of Appalachian forests, the smooth bluish stem and large single unfolding leaf of the blue cohosh plant (Caulophyllum thalictroides) stand out vividly against the surrounding bareness. As the plant grows, it blends in with the rest of the forest until late summer, when deep blue berries (which are actually seeds) attract the eye. Indian tribes used them to relieve rheumatism, colic, and menstrual cramps. Today, herbalists continue to use the roots to treat rheumatism.

By midsummer, fields and roads of the southern highlands are crowded with intricately patterned flat flower clusters of Queen Anne’s lace (Daucus carota), a member of the carrot family. Through the years, extracts from this widely distributed biennial were used medicinally as diuretics and to dissolve kidney stones. The seeds were eaten to eliminate intestinal worms and gas.

While extracts of Queen Anne’s lace are not generally used by today’s herbalist as a diuretic, research has confirmed their effectiveness in dispelling intestinal gas. The wild root is also rich in vitamin A, but care should be taken not to ingest it in excessive amounts. (Too much vitamin A can be harmful to your health.)

Another plant which is native to eastern North America, including the southern Appalachians, is the Oswego tea plant (Monarda didyma), sometimes also called bee balm. The name comes from the use of its aromatic leaves by the Oswego Indians of western New York and also the Shakers, who thought the tea to be effective in treating colds and sore throats. Still other settlers steamed the plant and inhaled the fumes to clear sinuses. Although medicinal use of the plant is no longer widespread, the aromatic oil of Oswego tea continues to be used in the perfume industry.

No trip through the southern Appalachians would be complete without acknowledging one of the most widespread plants — Mentha piperita — which is the botanical name for the well-known peppermint. It has the unusual feature of square stems and rootstocks that take root along the ground, enabling the plant to spread from one growing season to the next. The oil is obtained by steam distillation of the aboveground parts and is used in many medicinal products, particularly cold remedies.

Our journey through the southern Appalachians has touched on but a few of the myriad plants with healing properties. In fact, the area is such a rich source of medicinal plants that the S. B. Penick Company, a botanical drug corporation headquartered in New York, maintained a branch office in Asheville, N.C., for many years.

Since prehistoric times, humans have turned to plants for healing, and the quest has not ended in disappointment. Modern pharmacology will continue to look for new sources of “green medicine,” and one place to which it will surely return is the lush green forests of the southern Appalachians. For there has been, and will continue to be, healing in the mountains.

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The brain’s own self-enhancer is back on center stage

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zarkovPregnenolone is a master hormone from which the body produces many other hormones. But pregnenolone is also involved in learning and memory; it moderates aggression, epilepsy, stress responses, anxiety and depression; and it shows promise for treating fatigue, bipolar disorder, schizophrenia, dementia, and even arthritis!

Stress and fatigue.

Experiments in the 1940s showed that 50-100 mg/day of pregnenolone given to factory workers resulted in improved production rates, less fatigue, and an increase in happiness and well-being. Pilots reported less fatigue and an improved ability to fl y airplanes.
These effects occurred after about two weeks of pregnenolone usage.

Arthritis.

Also in the 1940s, rheumatoid arthritis was successfully treated with pregnenolone. At 300 mg/day for 40 days patients  experienced “a significant decrease in joint pain, tenderness, and spasticity, with improved strength and range of motion”.

But in the 1950s pregnenolone was pushed aside by new stimulants, painkillers and anti-inflammatories. By the time it was realized that long-term use of these newer drugs led to serious side effects, pregnenolone had become an unfashionable research topic.

During the past two decades, however, pregnenolone has been receiving renewed attention. Many scientific studies have suggested its use in patients with a variety of mental conditions.

Memory.

Pregnenolone is a powerful stimulator of memory formation — significant memoryenhancing effects have been seen in mice when just a few dozen molecules of pregnenolone sulfate are injected into certain areas of the brain. In a recent clinical study, a 500 mg oral dose of pregnenolone “resulted in improved memory in both men and women, improved spatial memory and perception in men, and improved verbal recall memory in women.”

Anxiety.

In patients with anxiety disorders, higher anxiety correlates with lower pregnenolone levels in the blood. Animal experiments have shown that anxiety is significantly reduced when pregnenolone is given to animals in stressful situations. Similar effects occur in humans, as shown by the stress studies in the 1940s. The suggested oral dosage range is 50-200 mg.
Depression and bipolar disorder.

Dozens of animal studies have convinced many investigators that pregnenolone is a promising treatment for psychiatric illnesses, including depression and bipolar disorder. The clinical trial dosage used for bipolar disorder is 50-100 mg/day.

Schizophrenia.

In a 2005 clinical trial, schizophrenia patients were given pregnenolone for 8 weeks in doses from 100 to 500 mg/day. The  researchers reported that patients “who have been on the higher dose … have felt better, with an improved sense of energy.”

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How toxins are making us fat and diabetic

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Each year the toxic burden in our air, food and water – and thus our bodies – grows higher than ever before. Companies manufacture 6.5 trillion pounds of 9,000 different chemicals each year. That’s an almost incomprehensible amount. But to put it in perspective, an ocean supertanker carries about 3.25 billion tons. It would take 10,000 supertankers to carry the amount of chemicals that are manufactured in a single year.

A recent study by the Environmental Working Group (EWG) found the average person has over 91 toxic chemicals in their body. Some people had as many as 165, including 76 known to cause cancer, 94 known to be toxic to the brain and nervous system, and 79 known to cause birth defects and abnormal fetal development.

Another EWG study found an average of 200 industrial compounds, pollutants, and other chemicals in the umbilical cord blood of 10 newborn babies. Chemicals found in the second study included the organochlorine pesticides DDT and dieldrin, perfluorochemicals, brominated fire retardants, PCBs, polyaromatic hydrocarbons, polychlorinated and polybrominated dioxins and furans, polychlorinated naphthalenes, and mercury.

If that wasn’t enough, the Standard American Diet itself is highly toxic. Processed and refined foods, industrial seed oils, high fructose corn syrup, and even so-called healthy foods like whole grains and soy all have a toxic effect on the body.

How environmental toxins cause diabesity

An increasing amount of evidence has linked exposure to toxins with both obesity and diabetes. Toxins cause inflammation and immune dysregulation. And as you know from reading this series, obesity and diabetes are autoimmune, inflammatory diseases.

I’ve already discussed the role of food toxins in the diabesity epidemic, so in this article we’re going to focus on how industrial chemicals in our air, water and soil contribute.

There are several mechanisms involved. Environmental toxins:

* interfere with glucose and cholesterol metabolism and induce insulin resistance;
* disrupt mitochondrial function;
* cause oxidative stress;
* promote inflammation;
* alter thyroid metabolism; and,
* impair appetite regulation.

There are probably other mechanisms that we don’t yet understand. But the ones I listed above are certainly enough to explain the link between toxins and diabesity.

Evidence supporting the role of toxins in the diabesity epidemic

A while back I wrote about a study showing that a chemical called bisphenol-A (BPA), found in packaged foods and beverages, causes obesity in mice.

A more recent study published in JAMA found that BPA increases the risk of diabetes, heart disease, and abnormal liver function.

A 2010 study in Environmental Health Perspectives found that exposure to organic pollutants leads to insulin resistance and metabolic dysfunction in rats.

A review paper by researchers in Korea reached a similar conclusion:

…the metabolic syndrome is the result of mitochondrial dysfunction, which in turn is caused by exposure to persistent organic pollutants.

A National Health and Nutrition Examination Survey 1999-2002 observed a significant correlation between blood levels of six common persistent organic pollutants and diabetes. Those who had the highest serum levels of pollutants had a dramatically higher risk for diabetes.

Canadian Aboriginals and Great Lakes sport fishermen both have higher rates of diabetes from eating contaminated seafood.

I could go on, but I think you get the point. Toxins are making us fat and diabetic.

Okay, so I’m toxic! What do I do about it?

The most obvious first step is to remove all food toxins from your diet. This means ditching processed and refined foods, industrial seed oils, and high fructose corn syrup, as well as grains, legumes and other foods with toxic effects on the body.

The second step is to take steps to reduce your exposure to chemicals at home. This means choosing non-toxic household cleaning, bath, beauty and hygiene products.

The third step is to support the body’s natural detoxification capacity so you can effectively deal with the toxins you do get exposed to. This is a crucial step, because no matter how careful we are, there’s no way to completely avoid toxins.

Compounds that support health liver detoxification include:

* Protective compounds like milk thistle and artichoke leaf extract
* Bile stimulants such as dandelion and curcumin
* Bile motility enhancers (cholagogues) like dandelion, beet juice and coffee enemas
* Antioxidants like vitamins C & E, zinc, selenium and lipoic acid

For those of you that would like some support in this area, I’ll be offering a “Paleo Detox” program sometime early next year. It’s a 30-day, supervised detoxification program incorporating a paleo diet, targeted nutrients to support healthy liver function, supportive and educational weekly meetings, and guidelines for integrating the positive changes you’ve made in the program into your day-to-day life. I will offer both local (SF Bay Area) and long-distance (via webinar) programs. Stay tuned for a future announcement on this.
Comment: For more information, or if you wish to discuss this topic, please visit our diet and health forum.

Chris Kresser, The Healthy Skeptic, Fri, 05 Nov 2010 08:32 CDT

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Aspartame: The Dangers of Using Artificial Sweetener

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Scientifically known as 1-aspartyl 1-phenylalanine methyl ester, consumers recognize aspartame in the forms of Equal, NutraSweet and Spoonful. Aspartame has three components: phenylalanine (50 percent), aspartic acid (40 percent) and methanol, also termed wood alcohol (10 percent). Those in support of this popular artificial sweetener, state that the two primary amino acids, which comprise 90 percent of aspartame by weight, are a harmless and natural part of our diet. They insist that aspartic acid is a naturally occurring neurotransmitter, which is present in the human central nervous system. This is only a partial truth.

Phenylalanine and aspartic acid are amino acids that are normally supplied by the foods we eat; however, they can only be considered natural and harmless when consumed in combination with other amino acids. On their own, they enter the central nervous system in abnormally high concentrations, causing aberrant neuronal firing and potential cell death. The neurotoxic effects of these amino acids, when consumed as isolates, can be linked to headaches, mental confusion, balance problems and possibly seizures.

The damage caused by excitotoxin food additives is not usually dramatic. In most instances, the effects are subtle, cumulative and develop over a prolonged period of time.

Excitotoxins have also been shown to stimulate the generation of free radicals (charged oxygen molecules with an unpaired electron). These can have a negative impact on tissues and organs outside the central nervous system. Evidence indicates that free radical production accelerates many degenerative illnesses such as atherosclerosis, cancer, coronary artery disease and arthritis. It comes as no surprise that joint pain is a major complaint among aspartame reactors (individuals who have reported adverse reactions).

Potentially more worrisome is the 10 percent of aspartame that is absorbed into the bloodstream as methanol (wood alcohol). The Environmental Protection Agency defines safe consumption as no more than 7.8 milligrams per day of this dangerous substance. A one-liter beverage, sweetened with aspartame, contains about 56 milligrams of wood alcohol, or eight times the EPA limit!

For one of the most comprehensive articles written on the subject follow the links to the Cognitive Enhancement Research Institute

http://www.ceri.com/aspart1.htm

http://www.ceri.com/aspart2.htm

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Why Fish Oils Work Swimmingly Against Inflammation and Diabetes

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Researchers at the University of California, San Diego School of Medicine have identified the molecular mechanism that makes omega-3 fatty acids so effective in reducing chronic inflammation and insulin resistance.

The discovery could lead to development of a simple dietary remedy for many of the more than 23 million Americans suffering from diabetes and other conditions.

Writing in the advance online edition of the September 3 issue of the journal Cell, Jerrold Olefsky, MD, and colleagues identified a key receptor on macrophages abundantly found in obese body fat. Obesity and diabetes are closely correlated. The scientists say omega-3 fatty acids activate this macrophage receptor, resulting in broad anti-inflammatory effects and improved systemic insulin sensitivity.

Macrophages are specialized white blood cells that engulf and digest cellular debris and pathogens. Part of this immune system response involves the macrophages secreting cytokines and other proteins that cause inflammation, a method for destroying cells and objects perceived to be harmful. Obese fat tissue contains lots of these macrophages producing lots of cytokines. The result can be chronic inflammation and rising insulin resistance in neighboring cells over-exposed to cytokines. Insulin resistance is the physical condition in which the natural hormone insulin becomes less effective at regulating blood sugar levels in the body, leading to myriad and often severe health problems, most notably type 2 diabetes mellitus.

Olefsky and colleagues looked at cellular receptors known to respond to fatty acids. They eventually narrowed their focus to a G-protein receptor called GPR120, one of a family of signaling molecules involved in numerous cellular functions. The GPR120 receptor is found only on pro-inflammatory macrophages in mature fat cells. When the receptor is turned off, the macrophage produces inflammatory effects. But exposed to omega-3 fatty acids, specifically docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the GPR120 receptor is activated and generates a strong anti-inflammatory effect.

“It’s just an incredibly potent effect,” said Olefsky, a professor of medicine and associate dean of scientific affairs for the UC San Diego School of Medicine. “The omega-3 fatty acids switch on the receptor, killing the inflammatory response.”

The scientists conducted their research using cell cultures and mice, some of the latter genetically modified to lack the GPR120 receptor. All of the mice were fed a high-fat diet with or without omega-3 fatty acid supplementation. The supplementation treatment inhibited inflammation and enhanced insulin sensitivity in ordinary obese mice, but had no effect in GPR120 knockout mice. A chemical agonist of omega-3 fatty acids produced similar results.

“This is nature at work,” said Olefsky. “The receptor evolved to respond to a natural product — omega-3 fatty acids — so that the inflammatory process can be controlled. Our work shows how fish oils safely do this, and suggests a possible way to treating the serious problems of inflammation in obesity and in conditions like diabetes, cancer and cardiovascular disease through simple dietary supplementation.”

However, Olefsky said more research is required. For example, it remains unclear how much fish oil constitutes a safe, effective dose. High consumption of fish oil has been linked to increased risk of bleeding and stroke in some people.

Should fish oils prove impractical as a therapeutic agent, Olefsky said the identification of the GPR120 receptor means researchers can work toward developing an alternative drug that mimics the actions of DHA and EPA and provides the same anti-inflammatory effects.

Co-authors of the paper are Da Young Oh, Saswata Talukdar, Eun Ju Bae, Hidetaka Morinaga, WuQuiang Fan, Pingping Li and Wendell J. Lu, all in the Department of Medicine, Division of Endocrinology and Metabolism at the University of California, San Diego; Takeshi Imamura, Division of Pharmacology, Shiga University of Medical Science; and Steven M. Watkins, Lipomics Technologies, Inc.

ScienceDaily (Sep. 2, 2010)

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